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Diclofenac potassium (CAS NO.: 100085-39-0) is a new non-steroidal anti-inflammatory medicine with significant anti-inflammatory and analgesic effects. Its mechanism of action is mainly to inhibit prostaglandin synthesis.
Diclofenac potassium is primarily used to treat osteoarthritis, rheumatoid arthritis, polymyositis and myodermatitis. Its function is immediate pain relief, such as migraine, toothache, biliary therapy, and kidney care. Medicinal diclofenac often excits as diclofenac sodium or diclofenac potassium.
Items | Standard |
Appearance | White or slightly yellowish, slightly hygroscopic, crystalline powder. |
Solubility | Sparingly soluble in water, free soluble in methanol, soluble in ethanol,slightly soluble in acetone. |
Identification | A. IR |
D. Tests of Potassium salt | |
Appearance of solution | The solution is clear |
UV 440nm NMT 0.05 | |
Related substances (HPLC) | Impurity A: NMT 0.15% |
Impurity F: NMT 0.15% | |
Any individual impurity NMT0.1% | |
Total impurities NMT 0.4% | |
Melt point | About 280℃,with decomposition |
Heavy metals | NMT 10ppm |
Loss on drying | NMT 0.5% (1.000g, 105,3 hrs) |
Assay | 99.0~101.0% (dried substance) |
Diclofenac potassium (CAS NO.: 100085-39-0) is a new non-steroidal anti-inflammatory medicine with significant anti-inflammatory and analgesic effects. Its mechanism of action is mainly to inhibit prostaglandin synthesis.
Diclofenac potassium is primarily used to treat osteoarthritis, rheumatoid arthritis, polymyositis and myodermatitis. Its function is immediate pain relief, such as migraine, toothache, biliary therapy, and kidney care. Medicinal diclofenac often excits as diclofenac sodium or diclofenac potassium.
Items | Standard |
Appearance | White or slightly yellowish, slightly hygroscopic, crystalline powder. |
Solubility | Sparingly soluble in water, free soluble in methanol, soluble in ethanol,slightly soluble in acetone. |
Identification | A. IR |
D. Tests of Potassium salt | |
Appearance of solution | The solution is clear |
UV 440nm NMT 0.05 | |
Related substances (HPLC) | Impurity A: NMT 0.15% |
Impurity F: NMT 0.15% | |
Any individual impurity NMT0.1% | |
Total impurities NMT 0.4% | |
Melt point | About 280℃,with decomposition |
Heavy metals | NMT 10ppm |
Loss on drying | NMT 0.5% (1.000g, 105,3 hrs) |
Assay | 99.0~101.0% (dried substance) |