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Griseofulvin is a potent oral antifungal medication used for treating skin and nail infections caused by dermatophytes. With a CAS number of 126-07-8, it effectively combats fungal infections like ringworm and impetigo in both humans and animals. Available in bulk, it is widely used in pharmaceutical applications for infection control.
Items | Standard |
Description | A white or yellowish-white,microfine powder. |
Particle size | The particles of which are generally up tp 5μm in max dimension |
Larger particles which may occasionally exceed 30μm | |
Melting point | About 220℃ |
Identification | The infrared absorbance spectrum is concordant with the reference spectrum |
A wine-red color develops | |
Appearance of solution | The solution is clear and not more intensely coloured than reference solution Y4 |
Acidity | Not more than 1.0ml of 0.02M sodium hydroxide is required |
Specific optical rotation | +354°~+364° |
Related Substances | -Cl:<0.60 |
-H:<0.15 | |
Substances soluble in light petroleum | ≤0.2% |
Loss on drying | ≤1.0% |
Sulphated ash | ≤0.2% |
Residual solvents | Ethanol≤0.5% |
Acctone≤0.5% | |
Dichoromethane≤0.06% | |
Abnormal toxicity | Five mice orals,none of die mice dies within 48h |
Assay(dried substance) | 97.0%~102.0% |
Appearance: White or off-white fine powder.
Particle Size: Maximum size generally does not exceed 5μm.
Melting Point: Approximately 220°C.
Identification: Consistent infrared absorption spectrum with reference spectrum.
Solution Appearance: Clear, color not exceeding reference solution Y4.
Acidity: Requires no more than 1.0ml of 0.02M sodium hydroxide solution for neutralization.
Skin Fungal Infections: Treats fungal infections like ringworm and nail fungus in both humans and animals.
Potential Cancer Treatment: Shows promise for use in cancer therapies.
Oral Use: Administered orally for the treatment of skin fungal diseases.
Inhibition Effects: Inhibits skin fungi such as dermatophytes, Microsporum, and Trichophyton.
Limitations: Ineffective against Malassezia furfur and Candida albicans.
1. What is Griseofulvin used for?
Griseofulvin is an oral antifungal medication used to treat skin and nail fungal infections in humans and animals. It is effective against various dermatophyte infections, such as ringworm and tinea.
2. What are the key applications of Griseofulvin?
Griseofulvin is used for treating skin fungal infections, such as cellulitis and impetigo. It has also shown potential in treating respiratory and digestive system infections. Additionally, it has been investigated for possible cancer treatment applications.
3. How does Griseofulvin work?
Griseofulvin works by inhibiting the growth of fungal cells. It interferes with fungal cell division, preventing the spread of the infection.
4. What is the recommended dosage for Griseofulvin?
The dosage varies depending on the type of infection being treated. Typically, Griseofulvin is administered orally. Please follow your healthcare provider's guidance for the proper dosage.
5. Is Griseofulvin safe for long-term use?
Griseofulvin is generally safe when used under a doctor's supervision. However, long-term use may require monitoring for potential side effects. Always consult with a healthcare professional before prolonged use.
6. What are the side effects of Griseofulvin?
Some common side effects include headaches, nausea, and gastrointestinal discomfort. Rare but serious side effects may include liver damage or allergic reactions. Always consult with a healthcare provider.
Griseofulvin is a potent oral antifungal medication used for treating skin and nail infections caused by dermatophytes. With a CAS number of 126-07-8, it effectively combats fungal infections like ringworm and impetigo in both humans and animals. Available in bulk, it is widely used in pharmaceutical applications for infection control.
Items | Standard |
Description | A white or yellowish-white,microfine powder. |
Particle size | The particles of which are generally up tp 5μm in max dimension |
Larger particles which may occasionally exceed 30μm | |
Melting point | About 220℃ |
Identification | The infrared absorbance spectrum is concordant with the reference spectrum |
A wine-red color develops | |
Appearance of solution | The solution is clear and not more intensely coloured than reference solution Y4 |
Acidity | Not more than 1.0ml of 0.02M sodium hydroxide is required |
Specific optical rotation | +354°~+364° |
Related Substances | -Cl:<0.60 |
-H:<0.15 | |
Substances soluble in light petroleum | ≤0.2% |
Loss on drying | ≤1.0% |
Sulphated ash | ≤0.2% |
Residual solvents | Ethanol≤0.5% |
Acctone≤0.5% | |
Dichoromethane≤0.06% | |
Abnormal toxicity | Five mice orals,none of die mice dies within 48h |
Assay(dried substance) | 97.0%~102.0% |
Appearance: White or off-white fine powder.
Particle Size: Maximum size generally does not exceed 5μm.
Melting Point: Approximately 220°C.
Identification: Consistent infrared absorption spectrum with reference spectrum.
Solution Appearance: Clear, color not exceeding reference solution Y4.
Acidity: Requires no more than 1.0ml of 0.02M sodium hydroxide solution for neutralization.
Skin Fungal Infections: Treats fungal infections like ringworm and nail fungus in both humans and animals.
Potential Cancer Treatment: Shows promise for use in cancer therapies.
Oral Use: Administered orally for the treatment of skin fungal diseases.
Inhibition Effects: Inhibits skin fungi such as dermatophytes, Microsporum, and Trichophyton.
Limitations: Ineffective against Malassezia furfur and Candida albicans.
1. What is Griseofulvin used for?
Griseofulvin is an oral antifungal medication used to treat skin and nail fungal infections in humans and animals. It is effective against various dermatophyte infections, such as ringworm and tinea.
2. What are the key applications of Griseofulvin?
Griseofulvin is used for treating skin fungal infections, such as cellulitis and impetigo. It has also shown potential in treating respiratory and digestive system infections. Additionally, it has been investigated for possible cancer treatment applications.
3. How does Griseofulvin work?
Griseofulvin works by inhibiting the growth of fungal cells. It interferes with fungal cell division, preventing the spread of the infection.
4. What is the recommended dosage for Griseofulvin?
The dosage varies depending on the type of infection being treated. Typically, Griseofulvin is administered orally. Please follow your healthcare provider's guidance for the proper dosage.
5. Is Griseofulvin safe for long-term use?
Griseofulvin is generally safe when used under a doctor's supervision. However, long-term use may require monitoring for potential side effects. Always consult with a healthcare professional before prolonged use.
6. What are the side effects of Griseofulvin?
Some common side effects include headaches, nausea, and gastrointestinal discomfort. Rare but serious side effects may include liver damage or allergic reactions. Always consult with a healthcare provider.